Side Effects of Varenicline: What to Expect When Quitting Smoking

Quitting smoking isn’t just a choice—it’s a battle, and like any major life shift, it comes with hurdles. If you’re thinking about or already using Varenicline (better known as Varnisam), you know it’s one of the most effective tools in the fight.

But let’s be real—it’s not a magic pill. There are challenges. Knowing the potential side effects of this smoking cessation treatment isn’t just helpful—it’s a must. Being informed means you can anticipate what’s ahead, manage any bumps in the road, and get the best results from this medication.

Why Varenicline Is a Game-Changer in Smoking Cessation

Before we get into the side effects, let’s take a moment to appreciate what Varenicline brings to the table. Unlike nicotine patches or gum, which simply provide a substitute for the nicotine hit, Varenicline goes straight for the brain’s nicotine receptors. It works by both reducing cravings and blocking the pleasure smokers typically get from a cigarette.

That’s huge. Because if you’ve ever wrestled with the temptation of “just one more,” you know how powerful that pull can be.

But here’s the kicker: while Varenicline can be a powerful tool in quitting smoking, it’s not without its quirks. And yes, that includes some potential side effects.

Common Side Effects: What Most People Experience

Every medication has its fine print, and Varenicline is no exception. Here are the most common side effects that were reported by users of this smoking cessation drug:

Less Common but Noteworthy Side Effects

Some side effects are rare—but worth knowing about. They may not affect most users, but staying informed can help you handle them if they arise:

1. Mood Changes

For some people, varenicline can trigger emotional shifts, including:

• Sudden mood swings
• Heightened irritability
• Unexplained feelings of sadness

These shifts can sometimes escalate into anxiety, depression, or unusual behavior patterns. If you’ve ever struggled with mental health concerns, it’s especially important to stay mindful of any changes.

Varenicline’s effects on mood during early abstinence are likely to play an important role in its clinical efficacy. Depression symptoms are common among smokers and motivate smoking to reduce negative affect (Varenicline Improves Mood and Cognition during Smoking Abstinence – PMC).

Varenicline has been linked to neuropsychiatric symptoms in certain users, so if you notice anything out of the ordinary—talk to your doctor.

2. Changes in Taste

A shift in taste perception is another potential side effect. Some users report that food tastes dull, metallic, or just… off.

This condition, known as dysgeusia, might even make cigarettes less appealing by altering the way tobacco tastes.

The Varenicline Pfizer data sheet states dysgeusia has been reported in studies at a rate ≥1% and with an incidence higher than that for placebo (A bitter pill to swallow – medicines that can cause taste disturbances – Medsafe).

While that might sound like a plus, it can also make everyday meals less enjoyable. If this starts to bother you, check in with your healthcare provider for advice on managing it.

3. Skin Reactions

Though uncommon, some individuals notice skin-related issues such as:

• Rashes
• Itching
• Increased sensitivity

These effects can range from mild irritation to more pronounced reactions. Keep an eye out for any persistent skin changes while on varenicline.

Moderate and severe skin reactions. Reported serious events included 338 cases of hives or swelling of the tongue, face, eyes, lips or other areas. In addition, 65 cases were classified as severe and included blisters, exfoliation of the skin and lips, and Stevens-Johnson Syndrome (Strong Safety Signal Seen for New Varenicline Risks – The Institute for Safe Medication Practices).

If a rash lingers, worsens, or spreads, it could be a sign of an allergic response—meaning it’s time to call your doctor.

Debunking the Scary Stuff: Severe Side Effects

You’ve probably heard about Varenicline’s potential for serious side effects like depression or suicidal thoughts. While these risks are rare, they’re not to be dismissed. Always monitor your mental health and reach out for help if you notice anything unusual.

Here’s the reassuring part: Many healthcare providers agree that the benefits of quitting smoking far outweigh these risks. Smoking itself contributes to anxiety, depression, and a laundry list of health issues. And keep in mind that varenicline is just one step in reclaiming your life from nicotine.

How to Make Varenicline Work for You

Want to get the most out of Varenicline while keeping side effects in check? Here’s how to do it right:

1. Ease Into It

Start with the prescribed starter pack—it’s designed to gradually increase your dosage over the first week. Why? Your body needs time to adjust.

This slow ramp-up reduces common side effects like nausea, making the experience smoother. Stick to your healthcare provider’s instructions—this phase is important for getting the best results.

2. Stay on Schedule

Timing matters. Take Varenicline at the same time every day, ideally after a meal and with a full glass of water.

Now, why does this help? Consistent timing keeps medication levels steady and that makes it more effective. Plus, a predictable routine can cut down on side effects like insomnia or those vivid dreams some users report.

3. Use It With Support

Here’s the deal: Varenicline works even better when paired with counseling or a support group. Why? Because quitting smoking isn’t just about breaking a habit—it’s about rewiring your mindset.

Behavioral support strengthens your decision, gives you practical coping strategies, and helps keep you on track. A well-rounded quit plan significantly increases your odds of long-term success.

Follow these steps, and you’ll be stacking the odds in your favor for a successful quit.

FAQs 

Can I drink alcohol while on Varenicline?

Moderation is your best friend here. Some users report increased sensitivity to alcohol while taking Varenicline, so it’s smart to start slow. Pay attention to how your body reacts before going for that second drink.

How long do the side effects last?

Most side effects are temporary—your body just needs time to adjust. Typically, they ease up within the first few weeks, so don’t panic if you experience mild discomfort early on.

Should I stop taking Varenicline if I experience side effects?

Not necessarily. Many side effects are manageable and tend to improve over time. That said, if something feels off, check in with your doctor before making any decisions about stopping or adjusting your dose.

Is weight gain a concern?

Weight gain is more about quitting smoking than the medication itself. When you stop smoking, your metabolism shifts, and cravings can kick in. Stay active, make mindful food choices, and you’ll be ahead of the game.

I missed a dose, what should I do?

Take the missed dose as soon as you remember, unless it’s close to your next scheduled dose. Never double up to make up for a missed pill.

Why It’s Worth It

Quitting smoking isn’t easy. It’s frustrating, emotional, and—let’s be honest—sometimes downright miserable. But the payoff? It’s massive. From finally catching your breath without wheezing to slashing your risk of life-threatening diseases, the benefits of quitting outweigh the temporary side effects of Varenicline. Every single time.

No two quitting journeys look the same, and you don’t have to go it alone. Varenicline is more than just a prescription—it’s a game-changer for breaking free from cigarettes. Armed with the right plan, support, and determination, you can do this.

Where to buy Varenicline

Here are the most reliable and trusted sites where you can purchase Varenicline (Varnisam):

If this article helped you, share it. That extra push could be the reason someone quits smoking—for good.