Apremilast is a medication that’s approved for treating moderate to severe plaque psoriasis in adults. It functions by inhibiting phosphodiesterase 4 (PDE4), an enzyme involved in inflammatory processes, thereby reducing inflammation associated with psoriasis.
Research Findings
Clinical studies have demonstrated its effectiveness.
In a phase 2b study, 29% of patients taking 20 mg of apremilast twice daily achieved a 75% reduction in the Psoriasis Area and Severity Index (PASI-75) at week 16, compared to 6% in the placebo group.
Real-world data also support its efficacy, with significant improvements observed in PASI scores, Dermatology Life Quality Index (DLQI), and Physician Global Assessment (PGA) after 4 and 16 weeks of treatment.
Noticeable Benefits
Apremilast has shown benefits across various psoriasis severities. In patients with mild to moderate plaque psoriasis, it demonstrated statistically significant and clinically meaningful improvements. For those with moderate to severe psoriasis, studies indicate substantial reductions in skin involvement and enhanced quality of life.
Safety Profile
Regarding safety, apremilast is generally well-tolerated. Common side effects include diarrhea, nausea, upper respiratory tract infections, and headaches. Most adverse events are mild to moderate in severity.
Where to buy Oral Apremilast
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