At the standard prescription dose of 120 mg taken three times daily with meals, orlistat can block approximately 30% of the fat from being absorbed by the body. This undigested fat is then excreted in the stool.
For the over-the-counter version, which contains 60 mg of orlistat, the fat absorption reduction is about 25%.
At the recommended therapeutic dose of 120 mg three times a
day, orlistat inhibits dietary fat absorption by approximately 30% (source: Xenical Capsules – FDA Access Data).
How Orlistat Works
Marketed under brand names like Xenical, Alli, and Orlinom, Orlistat is a weight loss medication that works by inhibiting lipase enzymes in the digestive system. These enzymes are responsible for breaking down dietary fats into smaller molecules that the body can absorb.
By blocking lipase activity, orlistat prevents the digestion and subsequent absorption of some of the fat consumed in meals.
How to Increase Orlistat’s Effectiveness
To increase the effectiveness of orlistat while managing obesity and minimize potential gastrointestinal side effects, it’s recommended to follow a diet where no more than 30% of daily calories come from fat.
In addition, since orlistat can reduce the absorption of fat-soluble vitamins (A, D, E, and K), it is better to take a multivitamin supplement at least two hours before or after orlistat.
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