Dapoxetine Science: What Causes It to Slow Ejaculation Down?

Premature ejaculation (PE) is a bigger problem than most men realize, but one of the most difficult sex topics to open up about. For someone with PE, this can be painful and stressful. That’s where Dapoxetine comes in, a prescription oral medication specifically engineered to slow down ejaculation and improve sexual performance. 

Let’s talk about what science is, what it does and why Dapoxetine is the go-to treatment for men suffering from early ejaculation in this post. You’ve either suffered from PE or you’re interested in understanding what this medication is and what it does, so here’s a detailed look. 

Why Should It Matter? 

Prior to diving into the weeds of Dapoxetine, it is important to appreciate why it is so important to grasp its mechanisms. PE doesn’t mean getting ahead – it means feeling confident, feeling mentally OK, and feeling fulfilled in a relationship.

Males shy away from getting help for fear of stigma, but if you know the science, it can be less of an obstacle and less intimidating. 

We want this article to help you know not only how Dapoxetine works, but how to make more informed choices when it comes to your sexual health.

What Is Dapoxetine?

Dapoxetine was the first oral drug to be approved to treat premature ejaculation. Instead of indirect PE control by extending the length of erection on other erectile dysfunction medications (such as Viagra), Dapoxetine directly affects timing of ejaculation. 

Currently, dapoxetine has the largest efficacy and safety database for use in men with PE, and it is the only agent for which SSRI class-related effects have been studied in a PE population (Efficacy of Dapoxetine in the Treatment of Premature Ejaculation).

Initially introduced as an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class, Dapoxetine wasn’t immediately popular among depression sufferers.

Yet scientists found that its short-term effects were tremendously helpful in prolonging ejaculation without the long-term negative effects of SSRIs. 

What Does Dapoxetine Do? 

But now comes the interesting bit, the science. Dapoxetine works by increasing serotonin in the brain. Serotonin is a neurotransmitter, a chemical that mediates communication between nerve cells. The higher levels of serotonin are responsible for mood, emotion and (very importantly for PE) ejaculatory control. 

An Overview of the Process

• Role of Serotonin In Ejaculation: Low serotonin levels in some brain areas are associated with ejaculation early on. As it expands your levels of serotonin, Dapoxetine inhibits the signaling that induces ejaculation, and keeps you in contact for longer. 
• Quick Intolerance and Action: It’s one of Dapoxetine’s special qualities to be able to act instantly. Dapoxetine has a speedy absorption rate, unlike older antidepressants, which may take weeks to accumulate in your body. That makes it not a once a day capsule but on-demand therapy. 
• Short Half-Life: Unlike most other SSRIs, the half-life of Dapoxetine is very short, i.e., it’s eliminated from the body in less than 24 hours. This lowers the incidence of adverse effects, making it safe for short-term use.

Why Dapoxetine Works for Ejaculation Delay 

Immediate Results 

Dapoxetine is unique because unlike other antidepressants it doesn’t take weeks of buildup. It is to be consumed instantly, 2-3 hours before sex. It’s for this speed of outcome that makes it so popular among PE males who want an action they can take quickly and trust. 

Minimal Side Effects 

Because Dapoxetine is so quickly absorbed, the chances of serious side effects in the long term are far reduced compared to SSRIs that have been widely used for PE. There are some users who might experience slight nausea, dizziness or headaches, but these are usually temporary and disappear when the drug has gone off the body. 

Further investigations have revealed dapoxetine to be a safe and effective treatment of PE (Porst et al., 2010), with mild side effects such as dizziness, nausea or diarrhea in 4–10% of patients (McMahon et al., 2011). Furthermore, men taking dapoxetine for PE have demonstrated no evidence of increased suicidal ideation or attempts, a side effect reported with other longer acting SSRI’s (McMahon et al., 2011) (Dapoxetine – an overview | ScienceDirect Topics).

Why Dapoxetine Does More Than Delay Ejaculation

Dapoxetine’s principal target is time, but the drug has wider applicability: 

• Increased Self-Esteem: Becoming aware that you are in control of your ejaculation will do wonders for your self-confidence and ease the pressure from performing. 
• Higher Levels of Relationship Satisfaction: Most men will feel they have more powerful, fulfilling relationships with their partner as they enter treatment. With PE treated, relationships have better closeness and emotional bonding. 
• Reduced Stress Regarding Sex: For most men, early ejaculation stress will put up a wall. That jitter goes away when you take Dapoxetine and sexual activity feels more easy and fun. 

Blending Dapoxetine with Other Medicines

For males who experience both premature ejaculation and ED, Dapoxetine may be stacked with other ED medications such as Tadalafil. The two medications solve different problems, and are therefore complementary.

Where Tadalafil works by preventing you from losing your erection, Dapoxetine keeps you going longer by delaying ejaculation. Win-win, right? 

Nonetheless, you should always consult with your physician before taking these in combination, as there can be interactions depending on your condition or other medications you might have. 

Who Should Stay Away From Dapoxetine?

Dapoxetine is safe on most people, but not everyone. Certain patients should avoid this medication: 

Common Side Effects and Expectations

Dapoxetine is generally a well-tolerated medicine, but there are some side effects to expect. Among the most common are: 

• Nausea 
• Dizziness 
• Headaches 
• Diarrhea 

Such side effects are typically mild and dissipate in the first few uses. Avoid alcohol and stay hydrated while taking Dapoxetine to reduce the possibility of dizziness. 

How to Take Dapoxetine Safely and Effectively? 

• Stick to the Doctor’s Directions: Only use Dapoxetine as per doctor’s instructions, approximately 1-3 hours before sex. 
• Do Not Drink Alcohol: Drinking alcohol makes you feel more dizzy or nauseous. If you’re going to drink, do so moderately or simply don’t drink. 
• Hydrate: Drink a lot of water to avoid dehydration-related side effects such as headaches or dizziness. 
• Give It Time: You may experience nausea or dizziness but these tend to go away as your body adapts to the medication. 

Then, is Dapoxetine For You? 

Dapoxetine is a science-backed alternative to premature ejaculation, and it has given many men that much-needed grip and assurance in their sexual lives.

If you’ve been struggling with PE and would like to own your experience, Dapoxetine could be your solution but you still have to check with your physician before you decide if it’s right for you. 

Where to buy Dapoxetine

Here are the most reliable and trusted sites where you can purchase Dapoxetine:

Do you have experience with Dapoxetine or premature ejaculation? Tell us what you think, what happened, and what you can recommend here—let’s be frank, and empower one another!