Rapamycin, originally approved to prevent organ transplant rejection, has garnered attention for its potential to extend lifespan and improve health.
This interest stems from its ability to inhibit the mammalian target of rapamycin (mTOR), a protein that regulates cell growth and metabolism. By suppressing mTOR activity, rapamycin may reduce inflammation and promote autophagy, a process that clears damaged cellular components.
Research Findings
Animal studies have demonstrated that rapamycin can prolong lifespan in species like yeast and mice.
For instance, mice treated with rapamycin lived approximately 12% longer than their untreated counterparts. These findings have led some researchers and longevity enthusiasts to explore rapamycin’s potential anti-aging effects in humans.
Improvements in Age-Related Issues
In humans, rapamycin and its derivatives have shown improvements in certain age-related physiological parameters, particularly within the immune, cardiovascular, and integumentary systems. However, no significant effects have been observed on the endocrine, muscular, or neurological systems.
Additionally, some individuals with age-related diseases experienced increased cholesterol levels and a higher incidence of infections when using these drugs.
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