Azelaic acid is one of those underrated skincare ingredients—especially if you struggle with acne, redness, or uneven skin tone. It fights breakouts, smooths skin, and tackles hyperpigmentation all in one go.
But how do you actually incorporate it into your routine without irritation or guesswork?
What Makes Azelaic Acid So Effective?
Azelaic acid isn’t just another trendy skincare ingredient—it’s backed by science. Naturally found in barley, wheat, and rye, it’s loaded with anti-inflammatory and antibacterial properties.
- Fights acne: Slows down acne-causing bacteria and keeps pores clear.
- Evens out skin tone: Targets hyperpigmentation and post-acne marks.
- Soothes inflammation: Reduces redness and irritation (hello, rosacea relief!).
Basically, if your skin is prone to breakouts, dullness, or uneven tone, this is an ingredient worth including in your regimen.
Picking the Right Azelaic Acid Product
Not all azelaic acid products are created equal.
It comes in creams, gels, and serums, with concentrations typically ranging from 10% to 20%. Here’s how to pick what’s right for you:
| Azelaic Acid Product | Strength | Why Choose This? |
|---|---|---|
| OTC Options | Up to 10% | Great for beginners or those with sensitive skin. Found in over-the-counter serums and creams. |
| Prescription Strength | 15-20% | If you need a stronger formula for stubborn acne or melasma, dermatologists often prescribe these. |
📌 Pro Tip: New to azelaic acid? Start low (10%) and work your way up. Your skin will thank you.
Combining Azelaic Acid with Other Actives
Azelaic acid is an effective ingredient. It fights acne, reduces redness, and brightens skin. But what happens when you mix it with other actives? Does it improve results or will it backfire?
Niacinamide: The Perfect Pairing
Think of azelaic acid and niacinamide as the ultimate skincare duo. Both have anti-inflammatory properties, making them a dream team for calming redness and irritation.
Niacinamide (a.k.a. vitamin B3) strengthens your skin barrier and speeds up healing. Meanwhile, azelaic acid works its magic by reducing pigmentation and acne-causing bacteria.
The result? Smoother, more even-toned skin—without the risk of irritation.
When combined, Niacinamide and Azelaic acid create a powerful punch against hyperpigmentation. Niacinamide’s melanin-inhibiting properties complement azelaic acid’s exfoliating and anti-inflammatory effects. This combination can help speed up the fading of dark spots while preventing new breakouts and minimizing redness (Azelaic Acid & Niacinamide Duo Benefits for Hyperpigmentation – Raw Beauty Wellness).
How to use it: Layer niacinamide first, then follow up with azelaic acid. Or, find a product that contains both.
Retinoids: Proceed with Caution
Retinoids are legendary for anti-aging and acne-fighting. Azelaic acid? Equally impressive. But together? It’s a high-stakes game.
Both ingredients accelerate skin renewal—but that also means increased irritation potential. The fix? Alternate nights.
This gives your skin time to adjust without getting red, dry, or flaky. If you’re unsure, a dermatologist can help you personalize your routine.
“When combining two powerful skincare ingredients, a gradual approach is always best,” says Dr. Lilliana Ramirez, a board-certified dermatologist and the Director of Skincare Success at Nava MD (Azelaic Acid and Retinol: The Perfect Match – Nava MD).
How to use it: Apply azelaic acid in the morning and retinoids at night. Or use them on different days to keep irritation at bay.
AHAs (Alpha-Hydroxy Acids): Exfoliation Overdrive
Azelaic acid plays well with AHAs (like glycolic or lactic acid), but there’s a fine line between glow and over-exfoliation.
Both acids remove dead skin cells, unclog pores, and refine texture. But too much can leave your skin sensitive, dry, or irritated.
What to do? Start slow.
How to use it: Use azelaic acid in the morning and AHAs at night—or alternate days. Listen to your skin.
Common Side Effects: What You Might Experience
Like anything powerful, azelaic acid comes with a few potential side effects—especially when you first start using it.
No need to panic. Most side effects are mild and temporary. But knowing what to expect (and how to handle them) will make your experience way smoother.
On topical application azelaic acid is well tolerated, with adverse effects apparently limited to a generally mild and transient local cutaneous irritation. Thus, topical azelaic acid, employed either as monotherapy or in combination with other treatments, is likely to prove of value in the management of acne and several hyperpigmentary disorders, most notably melasma (Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders – PubMed).
Your skin is adjusting. That’s normal. But here are a few things you might notice:
| Side Effect | What’s Going On |
|---|---|
| 🔥 Burning or Stinging Sensation | That slight tingling? Totally normal. Some people feel a mild burn or sting when azelaic acid hits the skin—especially at first. |
| 😣 Itching | As your skin gets used to azelaic acid, you might experience some itchiness. It’s just your skin acclimating to the treatment. |
| 🥶 Dryness & Peeling | Flaky skin? That’s your cell turnover speeding up. Azelaic acid exfoliates on a deep level, which can sometimes cause dryness and peeling in the beginning. |
| 😡 Redness | Some users see red patches in treated areas—especially if they jump into daily use too fast. |
These effects are temporary. But if they’re making your skin freak out, here’s how to deal with them.
How to Minimize Side Effects & Keep Your Skin Happy
1. Start Slow
This is the golden rule. Instead of slathering it on every night, ease in.
📌 How to do it:
- Use every other day at first.
- If your skin handles it well, gradually work up to daily use.
Let your skin build tolerance—it’ll thank you later.
2. Moisturize Like a Pro
Azelaic acid can be drying, so lock in moisture. A good moisturizer prevents flakiness and keeps your skin barrier strong.
📌 How to do it:
- Apply azelaic acid first, then follow up with a hydrating, fragrance-free moisturizer.
- Look for ingredients like ceramides, hyaluronic acid, or squalane to combat dryness.
3. Use Sunscreen (Yes, Really)
Azelaic acid doesn’t make your skin extra sun-sensitive like retinoids, but redness + sun exposure = a bad time.
📌 How to do it:
- Use a broad-spectrum SPF 30+ daily.
- Bonus: Sunscreen also helps prevent hyperpigmentation (which is why you’re using azelaic acid in the first place).
4. Skip the Harsh Stuff
Azelaic acid is gentle, but mixing it with aggressive ingredients = disaster.
📌 Avoid:
- Alcohol-based toners
- Fragranced skincare
- Harsh exfoliants (especially if your skin is already dry)
Stick to simple, barrier-friendly products to reduce irritation.
5. Consult a Dermatologist if Needed
Still dealing with persistent redness, peeling, or irritation? Time to bring in an expert.
📌 When to see a dermatologist:
- If your skin doesn’t adjust after a few weeks.
- If irritation is severe or uncomfortable.
- If you’re unsure whether azelaic acid is right for your skin type.
A derm can help tweak your routine—or recommend an alternative that plays nicer with your skin.
FAQs
Can I use azelaic acid during pregnancy?
Yes! Azelaic acid is one of the few skincare actives considered safe during pregnancy. It’s often recommended as an alternative to retinoids or salicylic acid, which should be avoided.
That said—always check with your healthcare provider before adding anything new to your routine. Better safe than sorry.
How long does it take to see results with azelaic acid?
Patience is important.
For most people, noticeable improvements start around 4 to 8 weeks of consistent use. If you’re tackling hyperpigmentation, it might take a little longer.
Stick with it. The results are worth it.
Can azelaic acid be used on sensitive skin?
Absolutely. Azelaic acid is known for being gentle yet effective, making it a great option for those with sensitive or redness-prone skin.
If you’re new to it, start slow: use a lower concentration and apply every other day before going daily. Your skin will thank you.
Is it necessary to use sunscreen when using azelaic acid?
100%. No debate.
Azelaic acid can increase sun sensitivity, meaning you’ll need a broad-spectrum SPF (at least 30) every single day.
Want to undo dark spots and keep your skin looking fresh? Sunscreen is non-negotiable.
Be Patient, Stay Consistent, and Get Ready for the Glow-up
Azelaic acid is effective—if you use it right.
Knowing how to layer it properly and pairing it with the right ingredients, will unlock its full potential. And if you ever feel stuck, a quick check-in with a dermatologist can help fine-tune your routine.
Glowy, clear skin is just a few weeks away. Stay consistent and enjoy the results.
Where to buy azelaic acid cream
Here are the most reliable and trusted sites where you can purchase Adapalene (Aziderm Cream):