What Are the Most Common Side Effects of Naltrexone?

man taking med

Naltrexone is a medication commonly prescribed to manage alcohol and opioid dependence. While it is generally well-tolerated, some individuals may experience side effects. The most frequently reported include:​

  • Nausea (and Vomiting): Nausea was the most common side effect, according to findings from a multicenter usage study.
  • Headache: Some individuals may experience headaches during treatment. ​
  • Dizziness: Feelings of lightheadedness or dizziness can occur, especially when standing up quickly.
  • Fatigue: A general sense of tiredness or low energy is reported by some patients.
  • Insomnia: Difficulty sleeping or changes in sleep patterns may be experienced.
  • Anxiety or Nervousness: Some individuals may feel increased anxiety or restlessness.
  • Abdominal Cramps and Pain: Discomfort or cramping in the stomach area can occur.
  • Joint and Muscle Pain: Aches in muscles or joints have been noted by some users.

It’s important to note that not everyone will experience these side effects, and some may encounter others not listed here. If side effects are persistent or concerning, it’s advisable to consult your doctor.

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